|
Showing 1 - 5 of
5 matches in All Departments
This detailed book explores the concepts and applications of
epigenome editing, as presented by leading scientists in the field.
Beginning with some general and topical reviews, the collection
continues by covering the design of DNA-binding devices,
optimization of the effector domains, readout of epigenome marks,
and approaches for delivery at the cellular and organismal level.
Written for the highly successful Methods in Molecular Biology
series, chapters include introductions to their respective topics,
lists of the necessary materials and reagents, step-by-step,
readily reproducible laboratory protocols, and tips on
troubleshooting and avoiding known pitfalls. Authoritative and
practical, Epigenome Editing: Methods and Protocols will be of
great assistance to people new to the field but also to those
already engaged, as epigenetic editing is still a relatively
unexplored field with many issues to be resolved.
This 2nd edition of the book on DNA methyltransferases has been
comprehensively updated to reflect many novel research findings
regarding the structure, function, and technology of these enzymes
that have emerged over the past 6 years. Like the previous edition,
this 2nd edition explains the biochemical properties of DNA
methyltransferases, describing their structures, mechanisms and
biological roles in bacteria, humans and plants. It also discusses
the biological processes of reading DNA methylation and the
mechanisms of DNA demethylation. This volume highlights the newest
findings on DNA methyltransferase inhibitors and their use in
cancer therapy as well as the latest epigenome editing systems
based on these enzymes. Overall, this 2nd edition comprehensively
summarizes the current state of research in the field of DNA
methylation and DNA methyltransferase and is essential reading for
early career and advanced researchers in this exciting field.
|
|